Mechanisms of action of therapeutic antibody
Therapeutic antibody has 3 typical mechanisms of action.
When ligands such as growth factor bind to their receptors, ligands activate target cells and cause damages.
When therapeutic antibody binds to its target, ligand or receptor, antibody interferes ligand-receptor interaction and prevents undesirable activities.
ADCC (Antibody-Dependent Cellular Cytotoxicity)
CDC is triggered by the binding of complement to the antibody bound to cell surface an antigen.
Activated complement system lyses the target cell.
In addition, therapeutic antibody treat diseases through a variety of mechanisms.