Kyowa Kirin Presents New Data for Mogamulizumab from Its Lead Program in Cutaneous T-cell Lymphoma (CTCL) at ASCOQuality of life and patient health outcomes data from the pivotal MAVORIC trial is being reported for the first time

Tokyo, Japan, June 4, 2018 --- Kyowa Hakko Kirin Co., Ltd., (Kyowa Kirin) announces that additional analyses from the pivotal MAVORIC trial are being presented at the Annual Meeting of the American Society of Clinical Oncology (ASCO), June 1-5, Chicago. MAVORIC was the open-label randomized multi-center phase 3 trial evaluated mogamulizumab versus vorinostat for the treatment of adult patients with relapsed or refractory mycosis fungoides (MF) or Sézary syndrome (SS) after at least one prior systemic therapy. MF and SS are the most common subtypes of cutaneous T-cell lymphoma (CTCL).

Progression free survival (PFS) was the primary endpoint; the results that demonstrated mogamulizumab had a clinically relevant and statistically significant increase in progression free survival over vorinostat have already been presented. Infusion reaction and rash were the most common adverse events associated with mogamulizumab. QOL measurements were secondary endpoints and included Skindex-29 (SDX-29), Functional Assessment of Cancer Therapy-General (FACT-G) and EuroQol-5D. SDX-29 and FACT-G were reported in ASCO.

"Quality of life may be severely impacted in patients living with CTCL, and the MAVORIC study included evaluation of the effect of both treatments on a range of QOL instruments," said Jeffrey S. Humphrey, M.D., President of Kyowa Kirin Development. "We are encouraged by the QOL data and look forward to working with investigators and patient advocates to further understand how mogamulizumab might help patients with MF and SS."

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